Advances in antiviral nucleoside analogues and their prodrugs
نویسندگان
چکیده
منابع مشابه
Antiviral activity of nucleoside analogues against norovirus.
BACKGROUND Norovirus (NoV) is the leading cause of epidemic gastroenteritis worldwide. The lack of a cell culture has significantly hampered the development of effective therapies against human NoV. Clinically approved nucleoside and non-nucleoside analogues have been used successfully against RNA viruses. METHODS In this study, we evaluated the efficacy of four nucleoside analogues (2'-C-MeC...
متن کاملAdvances in nucleoside monophosphate prodrugs as anti-HCV agents.
Nucleoside monophosphate prodrugs that are eventually bioconverted to the active nucleoside triphosphate (NTP) offer the potential to deliver increased intracellular NTP levels and/or organ-specific NTP enhancement. There are several classes of monophosphate prodrugs that have been applied to HCV drug discovery, and some of these approaches are currently being evaluated in humans. This review d...
متن کاملMedicinal chemistry of nucleoside phosphonate prodrugs for antiviral therapy.
Considerable attention has been focused on the development of phosphonate-containing drugs for application in many therapeutic areas. However, phosphonate diacids are deprotonated at physiological pH and thus phosphonate-containing drugs are not ideal for oral administration, an extremely desirable requisite for the treatment of chronic diseases. To overcome this limitation several prodrug stru...
متن کاملSynthesis Optimization of Some Nucleoside Analogues Derivatives and Their Antiviral Activity
To prepare the target nucleosides, the branched chain sugars was converted to their active form (1-bromosugar derivatives). This conversion included the hydrolysis of bromination with hydrobromic acid (HBr) in glacial acetic acid, forming 1-bromo sugars (4,6-di-O-Acetyl-2,3-dideoxy-3,3-di-C-nitro methyl-Darabinohexopyranosyl bromide), which were subjected to condensation with theophylline mercu...
متن کاملAntiviral Activity of 5-substituted Pyrimidine Nucleoside Analogues
From a large series of 5—substituted 1—(2—deoxy——D—ribofuranosyl)—ura— cil (dUrd) , 1—(2—deoxy——D—ribofuranosyl)—cytosine (dCyd) and 1—(—D—arabinofurano— syl)—uracil (araU) analogues that have been evaluated for their antiviral proper— ties, the (E)—5—(2—bromovinyl)derivatives emerged as the most potent and most selec— tive antiherpes agents. (E)—5—(2—Bromovinyl)—dUrd (BVDU) and its congeners, ...
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ژورنال
عنوان ژورنال: Antiviral Chemistry and Chemotherapy
سال: 2018
ISSN: 2040-2066,2040-2066
DOI: 10.1177/2040206618781410